Frequently Asked Question

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Adult stem cells are the powerful cells left behind during the process of growth and development from an embryo into a fully formed human being. They are present in a variety of tissues and organs in the adult human body, but doctors and researchers in the US have optimized the efficacy and safety of acquiring them from the hip bone2.

In adults, stem cells are present within a variety of tissues and organs. Due to ease of use and decades of history and optimization, bone marrow from the hip bone is the most commonly used source of adult stem cells in the US2.

During your adult stem cell therapy procedure, the doctor uses a needle to withdraw bone marrow from your posterior Iliac crest (lower back area). A trained nurse or technician then uses specifically designed equipment to concentrate the adult stem cells and growth factors in the bone marrow and returns the concentrated material for use as deemed appropriate by the physician1.

PRP, which comes from blood, is an indirect therapy. Stem cells respond to growth factors like the ones found in platelets. PRP’s success depends on the presence of stem cells in the environment and their ability to relocate in response to the presence of growth factors in PRP. In contrast, bone marrow cell therapy is a direct therapy. Within the bone marrow are adult stem cells, platelets, and growth factors. Not only does bone marrow cell therapy do the job of PRP therapy, but it also contains the active adult stem cells, which are vital to the healing process2.

No. The cells come from and are used in your own body, so the threat of rejection is miniscule to none2.

Any cell that does not come from your own body will be inferior to your own cells for one reason: they are foreign. Your immune system has a simple job: identify foreign cells/materials, and destroy them7. This is why organ transplant recipients must take anti-rejection drugs as long as they live. They have to keep their immune system from doing its job in order to keep their transplanted organ8. If a practitioner chooses to treat a patient with any cell type that is not the patient’s own cells, and that patient is not on anti-rejection drugs, the immune system will recognize the transplanted cells as foreign and clear them. Using your own cells is the only way to ensure that they will be accepted by your body.

Absolutely not. Cells derived from patients well into their 70s have been successfully used for orthopedic applications6, and the world’s foremost clinician researcher, Dr. Phillippe Hernigou, recently presented data showing that he has used cells from 90+ year old patients to successfully treat knee arthritis and pain.

Doctors draw bone marrow from your hip and then concentrate it using an FDA-cleared device. Unlike procedures which process fat with enzymes or use living foreign cells like amniotic products, bone mar- row concentration is carried out using your own cells with minimal manipulation, which meets the FDA’s definition of the practice of medicine9.

While adult stem cells have been used for decades to treat a variety of diseases, their application in the treatment of pain is relatively new. Because of this, insurance companies do not currently cover the therapy.

The cost of a stem cell treatment varies based on the procedure performed. Our office staff can assist you with payment options and any other questions you may have.

References

  1. Hernigou P, Homma Y, Flouzat Lachaniette CH, et al. Benefits of small volume and small syringe for bone marrow aspirations of mesenchymal stem cells. Int Orthop. 2013;37(11):2279-2287. doi:10.1007/s00264-013-2017-z
  2. Murphy MB, Moncivais K, Caplan AI. Mesenchymal stem cells: Environmentally responsive therapeutics for regenerative medicine. Exp Mol Med. 2013;45(11):e54-16. doi:10.1038/emm.2013.94
  3. Hernigou P. Percutaneous Autologous Bone-Marrow Grafting for Nonunions: Influence of the Number and Concentration of Progenitor Cells. J Bone Jt Surg. 2005;87(7):1430. doi:10.2106/JBJS.D.02215
  4. Hernigou P, Poignard A, Zilber S, Rouard H. Cell therapy of hip osteonecrosis with autologous bone marrow grafting. Indian J Orthop. 2009;43(1):40. doi:10.4103/0019- 5413.45322
  5. Pettine K, Suzuki R, Sand T, Murphy M. Treatment of discogenic back pain with autologous bone marrow concentrate injection with minimum two year follow-up. Int Orthop. 2016;40(1):135-140. doi:10.1007/s00264-015-2886-4
  6. Hernigou P, Homma Y, Flouzat-Lachaniette C-H, Poignard A, Chevallier N, Rouard